Profile details

Gliadin deamidated lgG
Total IgA*
Tissue Transglutaminase (IgA)

Code

GSA

Sample Reqs

B

Turnaround

2 days

Special instructions

To reduce the risk of missing IgA deficient patients, a Total IgA will be run for all low Tissue Transglutaminase IgA results. If IgA deficiency is identified, a reflex deamidated Gliadin IgG will be carried out to determine whether the patient is likely to have coeliac disease. Coeliac pathway:

1. Initial TTG IgA samples are received and tested
2. If TTG IgA is LOW <0.2 U/ml reflex testing for Total IgA will be undertaken
3. If Total IgA is LOW <0.1 g/L then reflex testing for deamidated Gliadin IgG test will be undertaken
4. If TTG IgA is HIGH >/= 10 U/ml then reflex testing for Endomysial IgA will be undertaken as a confirmatory test for first time positive samples.