HPV tests
Understanding the significance of HPV testing
The benefit of a negative HPV result is its negative predictive value (NPP). A negative HPV result indicates that a patient is a very low risk of developing cervical disease. However neither HPV testing not negative cervical cytology are able to reduce the risk to zero.The negative predictive value of both DNA and mRNA testing is the same.
Requests for HPV as the PRIMARY TEST will reflex to Cervical Cytology if HR-HPV is Detected/Positive at no additional charge.
Requests for HPV Primary Screening as a single test
HPV (A group of 14 HR mRNA types)
Code
HPVH
Sample Reqs
TPV
Turnaround
3 days
Special instructions
If HR-HPV is DETECTED/POSITIVE, cervical cytology (PAPT) will be processed without charge.
The PAPT will be processed from the same vial.
Requests for HP20 as a single test
HPV (28 individually typed LR & HR DNA subtypes)
Code
HP20
Sample Reqs
TPV
Turnaround
3 days
Special instructions
HPV low and high risk DNA subtypes will be reported individually (9 low and 19 high risk). If High Risk DNA subtypes are positive then Cervical Cytology (PAPT) using the same vial will be processed without charge.
Requests for HPVT as a single test
HPV (28 individually typed low risk (LR) & high risk (HR) DNA subtypes and reflexed mRNA for types 16, 18, 31, 33 and 45)
Code
HPVT
Sample Reqs
TPV
Turnaround
5 days
Special instructions
If one or more of DNA types 16, 18, 31, 33, 45 are DETECTED/POSITIVE, reflex testing for expression of E6/E7 oncogenes will be undertaken and Cervical Cytology (PAPT) will be processed without charge. The PAPT will be processed from the same vial.
Requests for Cervical Cytology as a single test are no longer processed without testing for HPV. In these circumstances, the HPV test will be charged in addition to the Cervical Cytology.
Requests for Cervical Cytolopgy (PAPT)
Cervical Cytology
Code
PAPT
Sample Reqs
TPV
Turnaround
6 days (combined report)
Special instructions
If PAPT is requested as a single test, HR-HPV will be undertaken additionally, and a combined report will be issued. PAPT and HPVH will be charged as two separate tests.
Cervical Cytology + HPVH
Code
PAPT + HPVH
Sample Reqs
TPV
Turnaround
6 days (combined report)
Special instructions
If PAPT and HPVH are requested together, results will be given as a combined report. PAPT and HPVH will be charged as two separate tests.
Requests for Cervical Cytology (PAPT) with selected HPV (HPVH or HP20 or HPVT)
Cervical Cytology +HPVH
Code
PAPT + HPVH
Sample Reqs
TPV
Turnaround
6 days (combined report)
Special instructions
Where HPV result is reported with Cervical Cytology, a recommendation for patient management will be given, based on the combined findings.
Cervical Cytology + HP20
Code
PAPT + HP20
Sample Reqs
TPV
Turnaround
6 days (combined report)
Special instructions
Where HPV result is reported with Cervical Cytology, a recommendation for patient management will be given, based on the combined findings.
Cervical Cytology + HPVT
Code
PAPT + HPVT
Sample Reqs
TPV
Turnaround
6 days (combined report)
Special instructions
Where HPV result is reported with Cervical Cytology, a recommendation for patient management will be given, based on the combined findings.
HPV/PAPT Combined Report
Where HPV result is reported with Cervical Cytology, a recommendation for patient management will be given, based on the combined findings.
Turnaround times are from receipt of sample in the Cervical Cytology laboratory.