Allergen Components have a wide variety of uses – from the diagnosis and management of allergic patients to the selection of patients suitable for Specific Immunotherapy. Use of Component Resolved Diagnostics (CRD) has fast become an interesting and probably essential part of allergy diagnostics. Allergens, such as a species of pollen, a mite or a food are composed of a number of different ‘potential’ allergenic molecules that may cause sensitisation. A much more precise and detailed picture of the patient’s sensitisation pattern can be obtained by measuring IgE to the components. This gives more information for the management of an allergen-sensitised individual indicating whether, for example, symptoms are likely to be severe and ultimately leads to better patient care.

 

ALTERNARIA COMPONENTS

All tests can be requested indivdually

m6
m229

Alternaria alternata
rAlt a1

 

ZZ1
B

 

ASPERGILLUS COMPONENTS

Aspergillus fumigatus allergen components

m3
m218
m219
m220
m221

m222

Asperillus fumigatus
rAsp f 1
rAsp f 2
rAsp f 3
rAsp f 4
rAsp f 6

 

ZZ2
B

 

BIRCH COMPONENTS

Birch allergen components (Betula verrucosa)

t3
t215
t216
t220
t225

Betula verrucosa (Silver Birch)
rBet v 1
rBet v 2
rBet v 4
rBet v 6


PR-10
Profilin
Ca binding protein

ZZ3
B

 

BRAZIL COMPONENTS

Brazil allergen components (Bertholletia excelsa)

f18
f354

Brazil Nut
rBer e 1


Storage protein 2S albumin

ZZ4
B

 

CAT COMPONENTS

Cat allergen components (Felis domesticus)

e1
e94
e220

Cat
rFel d 1
nFel d 2

Cat dander
Uteroglobulin
Serum Albumin

ZZ5
B

 

CELERY COMPONENTS

Celery allergen components (Apium graveolens)

f85
f417

Celery
rApi g 1.01


PR-10

ZZ6
B

 

COW'S MILK COMPONENTS

Cow's milk allergen components (Bos domesticus)

f2
f76
f77
e204
f78
f334

Milk
nBos d 4
nBos d 5
nBos d 6
nBos d 8
nBos d lactoferrin


a-lactalbumin
b-lactoglobulin
BSA cow
Casein milk
Lactoferrin

ZZ7
B

 

DOG COMPONENTS

Dog allergen components (Canis familiaris)

e5
e101
e102
e221

Dog
rCan f 1
rCan f 2
nCan f 3

Dog dander
Lipocalin
Lipocalin
Serum Albumin

ZZ8
B

 

EGG COMPONENTS

Egg allergen components (Gallus domesticus)

f1
f75
f233
f232
f323
k208

egg white
egg yolk
nGal d 1
nGal d 2
nGal d 3
nGal d 4



Ovomucoid
Ovalbumin
Conalbumin
Lysozyme

ZZ9
B

 

FISH COMPONENTS

Fish Allergen
Carp allergen components (Cyprinus carpio)
Cod allergen component (Gadus morhua)

f3
f355
f426

Cod
rCyp c 1
rGad c 1


Parvalbumin
Parvalbumin

ZZ10
B

 

HAZELNUT COMPONENTS

Hazel Components (Corylus avellana)

f17
f428
f425

Hazel Nut
rCor a 1
rCor a 8


PR-10
LTP

ZZ11
B

 

HOUSE DUST MITE COMPONENTS

House Dust Mite (Dermatophagoides pteronyssinus)

d1
d202
d203
d205

House Dust Mite
nDer p 1
rDer p 2
rDer p 10




Tropomyosin

ZZ12
B

 

KIWI COMPONENTS

Kiwi components (Actinidia deliciosa)

f84
f430

Kiwi
rAct d 8

PR10

ZZ32
B

 

LATEX COMPONENTS

Latex allergen components (Hevea brasiliensis)

k82
k215
k217
k218
k219
k220
k221
k222
k224

Latex
rHev b 1
rHev b 3
rHev b 5
rHev b 6.01
rHev b 6.02
rHev b 8
rHev b 9
rHev b 11







Profilin

ZZ13
B

 

OLIVE COMPONENTS

Olive allergen components (Olea europaea)

t9
t224

Olive
nOle e 1

 

ZZ14
B

 

PEACH COMPONENTS

Peach allergen components (Prunus persica)

f95
f419
f420
f421

Peach
rPru p 1
rPru p 3
rPru p 4


PR-10
LTP
Profilin

ZZ15
B

 

PEANUT COMPONENTS

Peanut allergen components (Arachis hypogaea)

f13
f422
f423
f424
f352
f427

Peanut
rAra h 1
rAra h 2
rAra h 3
rAra h 8
rAra h 9


7S globulins
2S albumins
11S globulin
PR-10
LTP

ZZ16
B

 

SHRIMP COMPONENTS

Shrimp allergen components (Penaeus aztecus)

k24
f351

Shrimp
rPen a 1


Tropomysin

ZZ17
B

 

SOYBEAN COMPONENTS

Soybean allergen components (Glycin max)

f14
f353
f431
f432

Soya
rGly m 4
nGly m 5
nGLy m 6


PR-10
beta-conglycinin
glycinin

ZZ18
B

 

TIMOTHY GRASS COMPONENTS

Timothy grass allergen components (Phelum pratense)

g6
g205
g206
g208
g215
g209
g210
g211
g212

Timothy
rPhl p 1
rPhl p 2
nPhl p 4
rPhl p 5b
rPhl p 6
rPhl p 7
rPhl p 11
rPhl p 12


Grass Group 1
Grass Group 2

Grass Group 5


Ca Binding Protein

Profilin

ZZ19
B

 

VENOM COMPONENTS

Venoms

I208
i210
i209
i211

rApi m 1
rPol d 5
rVes v 5
rVes v 1

Phospholipase A2, Honey Bee
European Paper Wasp
Common wasp
Phospholipase A1, Common Wasp






Proteins found in insect venoms. Specific markers particularly important when considering venom immunisation.

ZZ33
B

 

WALL PELLITORY COMPONENTS

Wall pellitory allergen components (Parietaria judaica)

w21
w211

Wall Pellitory
rPar j 2


LTP

 

ZZ20
B

 

WHEAT COMPONENTS

Wheat allergen components (Triticum aestivum))

f4
f416

Wheat
rTri a 19


Omega-5 Gliadin

 

ZZ21
B

 

PR-10 PROTEINS

PR-10 Proteins

t215
f428
f419
f353
f352
f417
f430

rBet v 1
rCor a 1
rPru p 1
rGly m 4
rAra h 8
rApi g 1.01
rAct d 8

PR-10
PR-10
PR-10
PR-10
PR-10
PR-10
PR-10

 

A heat labile protein, cooked foods are often tolerated.
Often associated with local symptoms such as Oral AllergySyndrome (OAS).
Often associated with allergic reactions to fruit and Vegetables in Northern Europe.

ZZ22
B

 

LIPID TRANSFER PROTEINS

Lipid transfer proteins

f420
f425
f427
w211

rPru p 3
rCor a 8
rAra h 9
rPar j 2

LTP
LTP
LTP
LTP


A stable protein to heat and digestion causing reactions to cooked foods.
Often associated with systemic and more severe reactions in addition to OAS.
Often associated with allergic reactions to fruit and vegetatables in Southern Europe.

ZZ23
B

 

PROFILINS

Profilins

t216
f421
g212
k221

rBet v 2
rPru p 4
rPhl p 12
rHev b 8

Profilin
Profilin
Profilin
Profilin


Seldom associated with clinical symptoms but may cause demonstrable or even severe reactions in a small minority of cases.

ZZ24
B

 

POLCALCINS

Polcalcins

t220
g210

rBet v 4
rPhl p 7

Ca binding protein
Ca binding protein

ZZ25
B

 

SEED STORAGE PROTEINS

Seed storage proteins

f423
f354
f431
f432
f422
f424
f416

rAra h 2
rBer e 1
nGly m 5
nGly m 6
rAra h 1
rAra h 3
rTri a 19

2S albumins
2S albumins
beta-glycinin
glycinin
7S globulins
11S globulin
Omega-5 Gliadin

Protein found in seeds serving as source material during growth of new plant.
Often stable and heat resistant proteins causing reactions also in cooked foods.

ZZ26
B

 

GLYCAN DETERMINANTS

Glycan determinants

o214

MUXF3 CCD

Bromelin

A marker for sensitisation to cross reactive-reactivity between species.
Seldom associated with clinical symptoms but may cause demonstrable or even severe reactions in a small minority of patients.

ZZ27
B

 

LIPOCALINS

Lipocalins

e101
e102

rCan f 1
rCan f 2

Lipocalin
Lipocalin

Very stable proteins. Allergen components displaying limited cross-reactivity between species.

ZZ28
B

 

PARVALBUMINS

Parvalbumins

f355
f426

rCyp c 1 (Carp)
rGad c 1 (Cod)

Parvalbumin
Parvalbumin

A major allergen in fish. A marker for cross-reactivity among different species of fish and amphibians.
A protein stable to heat and digestion causing reactions to cooked foods.

ZZ29
B

 

SERUM ALBUMINS

Serum albumins

e204
e220
e221
e222

nBos d 6
nFel d 2
nCan f 3
nSus s

Serum Albumin cow
Serum Albumin cat
Serum Albumin dog
Serum Albumin pig

A common protein present in different biological fluids and solids.
Cross-reactions between albumins from different animal species are well known for example between cat, dog, cow and pork.

ZZ30
B

 

TROPOMYOSINS

Tropomyosins

f351
d205

rPen a 1
rDer p 10

Tropomyosin
Tropomyosin

An actin-binding protein in muscle fibres.
A marker for cross-reactivity between crustaceans, mites and cockroach.

ZZ31
B